Born in 1452

Feb 6 Joanna Princess of Portugal a Portuguese saint, Regent and princess of the House of Aviz, daughter of King Afonso V of Portugal and his first wife Isabella of Coimbra.
Feb 14 Pandolfo Petrucci a ruler of the Italian city of Siena during the Renaissance.
Mar 10 Ferdinand II of Aragon in his own right the King of Sicily from 1468 and King of Aragon from 1479. As a consequence of his marriage to Isabella I, he was King of Castile jure uxoris as Ferdinand V from 1474 until her death in 1504. He was recognised as regent of Castile for his daughter and heir, Joanna, from 1508 until his own death. In 1504, after a war with France, he became King of Naples as Ferdinand III, reuniting Naples with Sicily permanently and for the first time since 1458. In 1512, he became King of Navarre by conquest after asserting a hereditary claim
Apr 15 Leonardo da Vinci an Italian polymath, painter, sculptor, architect, musician, mathematician, engineer, inventor, anatomist, geologist, cartographer, botanist, and writer. He is widely considered to be one of the greatest painters of all time and perhaps the most diversely talented person ever to have lived. His genius, perhaps more than that of any other figure, epitomized the Renaissance humanist ideal. Leonardo has often been described as the archetype of the Renaissance Man, a man of "unquenchable curiosity" and "feverishly inventive imagination". According to art historian Helen Gardner, the scope and depth of his interests were without precedent and "his mind and personality seem to us superhuman, the man himself mysterious and remote". Marco Rosci states that while there is much speculation about Leonardo, his vision of the world is essentially logical rather than mysterious, and that the empirical methods he employed were unusual for his time
Apr 19 Frederick of Naples the last King of Naples of the Neapolitan branch of the House of Trastámara, ruling from 1496 to 1501. He was the second son of Ferdinand I, younger brother of Alfonso II, and uncle of Ferdinand II, his predecessor
Jul 27 Ludovico Sforza Duke of Milan from 1489 until 1500. A member of the Sforza family, he was the second son of Francesco I Sforza. He was famed as a patron of Leonardo da Vinci and other artists, and presided over the final and most productive stage of the Milanese Renaissance. He is probably best known as the man who commissioned The Last Supper
Jul 27 Lucrezia Crivelli a mistress of Ludovico Sforza, il Moro, Duke of Milan. She was the mother of Sforza's son, Giovanni Paolo I Sforza, Marquess of Caravaggio. Crivelli has been thought to be the subject of Leonardo da Vinci's painting, La belle ferronnière
Aug 12 Abraham Zacuto a Sephardi Jewish astronomer, astrologer, mathematician, rabbi and historian who served as Royal Astronomer in the 15th century to King John II of Portugal. The crater Zagut on the Moon is named after him
Sep 21 Girolamo Savonarola an Italian Dominican friar and preacher active in Renaissance Florence, and known for his prophecies of civic glory, destruction of secular art and culture, and calls for Christian renewal. He denounced clerical corruption, despotic rule and the exploitation of the poor. He prophesied the coming of a biblical flood and a new Cyrus from the north who would reform the Church. This seemed confirmed when Charles VIII of France invaded Italy and threatened Florence. While Savonarola intervened with the king, the Florentines expelled the ruling Medici and, at the friar’s urging, established a "popular" republic. Declaring that Florence would be the New Jerusalem, the world center of Christianity and "richer, more powerful, more glorious than ever", he instituted an extreme puritanical campaign, enlisting the active help of Florentine youth
Oct 2 Richard III of England King of England from 1483 until his death in 1485 in the Battle of Bosworth Field. He was the last king of the House of York and the last of the Plantagenet dynasty. His defeat at Bosworth Field, the last decisive battle of the Wars of the Roses, marks the end of the Middle Ages in England. He is the subject of the play Richard III by William Shakespeare
Dec 10 Johannes Stöffler a German mathematician, astronomer, astrologer, priest, maker of astronomical instruments and professor at the University of Tübingen.