Born in 1459

Feb 1 Conrad Celtes a German Renaissance humanist scholar and Neo-Latin poet.
Mar 2 Pope Adrian VI the 218th pope of the Catholic Church from 9 January 1522 until his death on 14 September 1523.
Mar 6 Jakob Fugger a major merchant, mining entrepreneur and banker of Europe. He was a descendant of the Fugger merchant family located in the Free Imperial City of Augsburg, where he was also born and later also elevated through marriage to Grand Burgher of Augsburg. Within a few decades he expanded the family firm to a business operating in all of Europe. He began his education at the age of 14 in Venice, which also remained his main residence until 1487. At the same time he was a cleric and held several prebendaries, even though he never lived in a monastery
Mar 22 Maximilian I Holy Roman Emperor King of the Romans from 1486 and Holy Roman Emperor from 1508 until his death, though he was never in fact crowned by the Pope, the journey to Rome always being too risky. He had ruled jointly with his father for the last ten years of his father's reign, from 1483. He expanded the influence of the House of Habsburg through war and his marriage in 1477 to Mary of Burgundy, the heiress to the Duchy of Burgundy, but he also lost the Austrian territories in today's Switzerland to the Swiss Confederacy
Apr 15 Filippino Lippi an Italian painter working during the High Renaissance in Florence, Italy.
Oct 6 Martin Behaim a German mariner, artist, cosmographer, astronomer, philosopher, geographer and explorer in service to the King of Portugal.
Dec 22 Sultan Cem a pretender to the Ottoman throne in the 15th century.
Dec 27 John I Albert King of Poland and Duke of Głogów.