Born in 1478

Feb 3 Edward Stafford 3rd Duke of Buckingham an English nobleman. He was the son of Henry Stafford, 2nd Duke of Buckingham, and Katherine Woodville, whose sister, Queen Elizabeth Woodville, was the wife of King Edward He was convicted of treason, and executed on 17 May 1521
Feb 7 Thomas More an English lawyer, social philosopher, author, statesman and noted Renaissance humanist. He was an important councillor to Henry VIII and Lord Chancellor from October 1529 to 16 May 1532. More opposed the Protestant Reformation, in particular the theology of Martin Luther and William Tyndale. More also wrote Utopia, published in 1516, about the political system of an ideal and imaginary island nation. More later opposed the King's separation from the Catholic Church and refused to accept him as Supreme Head of the Church of England because it denied papal authority and he also opposed Henry's marriage to Anne Boleyn. Tried for treason, More was convicted, likely due to perjured testimony, and beheaded
May 26 Pope Clement VII Pope from 19 November 1523 to his death in 1534.
Jul 2 Louis V Elector Palatine a member of the Wittelsbach dynasty was prince elector of the Palatinate. His parents were Philip, Elector Palatine, and Margaret, a daughter of Louis IX, Duke of Bavaria-Landshut
Jul 8 Gian Giorgio Trissino an Italian Renaissance humanist, poet, dramatist, diplomat, and grammarian.
Jul 13 Giulio d'Este the illegitimate son of Ercole I d'Este, Duke of Ferrara, the result of an affair with Isabella Arduin, a lady in the service of Ercole's wife. He is known for the conflicts he had with his half brother Ippolito d'Este, which culminated in a failed conspiracy that Giulio conducted against both Ippolito and another half brother Alfonso I d'Este, then Duke of Ferrara
Jul 15 Barbara Jagiellon a princess of Poland and a Duchess of Saxony.
Jul 22 Philip I of Castile the first member of the house of Habsburg to be King of Castile. The son of Holy Roman Emperor Maximilian I, at age 3 Philip inherited the greater part of the Duchy of Burgundy and the Burgundian Netherlands from his mother, Mary, and at 27 briefly succeeded to the Crown of Castile as the husband of Queen Joanna, who was also heiress-presumptive to the Crown of Aragon. He was the first Habsburg monarch in Spain. He never inherited his father's territories, nor became Holy Roman Emperor, because he predeceased his father, but his son Emperor Charles V eventually united the Habsburg, Burgundian, Castilian, and Aragonese inheritances
Oct 1 Günther Zainer the first printer in Augsburg, where he worked from 1468 until his death; he produced about 80 books including two German editions of the Bible and the first printed calendar. He came to Augsburg from Strassburg and printed in 1472–76 three large works of moral instruction. He also printed the first large illustrated book, Jacobus de Voragine's Legenda aurea in 2 volumes with 131 woodcuts, 1471–76. Johann Zainer, the first printer in Ulm, was probably his brother
Dec 6 Baldassare Castiglione an Italian courtier, diplomat, soldier and a prominent Renaissance author.