Born in 1481

Jan 15 Ashikaga Yoshizumi the 11th shogun of the Ashikaga shogunate who reigned from 1494 to 1508 during the Muromachi period of Japan. He was the son of Ashikaga Masatomo and grandson of the sixth shogun Ashikaga Yoshinori. Yoshizumi was first called Yoshitō , then Yoshitaka
Mar 2 Franz von Sickingen a German knight, one of the most notable figures of the first period of the Reformation.
Mar 7 Baldassare Peruzzi an Italian architect and painter, born in a small town near Siena and died in Rome. He worked for many years with Bramante, Raphael, and later Sangallo during the erection of the new Peter's. He returned to his native Siena after the Sack of Rome where he was employed as architect to the Republic. For the Sienese he built new fortifications for the city and designed a remarkable dam on the Bruna River near Giuncarico. He seems to have moved back to Rome permanently by 1535
May 14 Ruprecht of the Palatinate (Bishop of Freising) the third son of Philip, Elector Palatine of the House of Wittelsbach and he was Bishop of Freising from 1495 to 1498.
Jul 1 Christian II of Denmark reigned as King of Denmark and Norway from 1513 until 1523 and of Sweden from 1520 until 1521. He was the oldest son of King John and belonged to the House of Oldenburg. Denmark was then an elective monarchy in which the nobility elected the new king, who had to share his power with them. After his short reign in Sweden, where he was also known as Christian the Tyrant , he was deposed by the nobleman Gustav Vasa. His reign in Denmark and Norway was cut short when his uncle deposed him and took the thrones as Frederick Christian was then exiled to the Netherlands, then ruled by his brother-in-law, Holy Roman Emperor Charles V
Aug 12 Jorge de Lencastre Duke of Coimbra a Portuguese Prince, illegitimate son of King John II of Portugal and Ana de Mendonça, a maid of Joanna la Beltraneja. He became the second Duke of Coimbra in 1509. He was also master of the Order of Santiago and administrator of the Order of Aviz from 1492 to 1550
Aug 28 Francisco de Sá de Miranda For the 19th century Venezuelan politician with similar name, see Francisco de Miranda.
Aug 30 Mikhailo Olelkovich a noble from the Olelkovich family of the Grand Duchy of Lithuania. He was the brother of Prince Semen Olelkovich of Kiev and cousin of Grand Prince Ivan III of Moscow. Mikhailo was allegedly involved both in bringing the Judaizer Heresy to Novgorod and the failed defection of the city to the Grand Duchy of Lithuania in 1471. He also organized a coup against Casimir IV Jagiellon, King of Poland and Grand Duke of Lithuania, but was discovered and executed in 1481. Mikhailo's son Semen continued the family line