Born in 1498

Feb 4 George I of Württemberg-Mömpelgard a son of the Duke Henry of Württemberg and his second wife, the Countess Eva of Salm.
Apr 5 Giovanni dalle Bande Nere an Italian condottiero.
Apr 9 Jean Cardinal of Lorraine a French cardinal, who was archbishop of Reims, Lyon and Narbonne, bishop of Metz, Toul, Verdun, Thérouanne, Luçon, Albi, Valence, Nantes and Agen. He is sometimes known as the cardinal de Lorraine
Jun 1 Maarten van Heemskerck a Dutch portrait and religious painter, who spent most of his career in Haarlem. He was a pupil of Jan van Scorel, and adopted his teacher's Italian-influenced style. He spent the years 1532–6 in Italy. He produced many designs for engravers, and is especially known for his depictions of the Wonders of the World
Jun 30 Wilhelm von Brandenburg the Archbishop of Riga from 1539 to 1561.
Aug 23 Miguel da Paz Prince of Portugal a Portuguese royal infante , son of King Manuel I of Portugal and his first wife Isabella of Asturias. He was recognised as heir both to his father's kingdom of Portugal, and to his grandparents' kingdoms of Castile, León and Aragon. As such, he was styled Prince of Portugal, Prince of Asturias and Prince of Girona
Nov 15 Eleanor of Austria born an Archduchess of Austria and Infanta of Castile from the House of Habsburg, and subsequently became Queen consort of Portugal and of France. She also held the Duchy of Touraine as dower. She is called "Leonor" in Spanish and Portuguese and "Eléonore" or "Aliénor" in French
Nov 30 Andrés de Urdaneta a Spanish circumnavigator, explorer and Augustinian friar. As a navigator he achieved in 1536 the "second" world circumnavigation. Urdaneta discovered and plotted a path across the Pacific from the Philippines to Acapulco in the Viceroyalty of New Spain used by the Manila galleons, which came to be known as "Urdaneta's route." He was considered as "protector of the Indians" for his treatment of the Filipino natives; also Cebu and the Philippines' first prelate
Dec 19 Andreas Osiander a German Lutheran theologian.