Born in 1499

Jan 6 John of Ávila a Spanish priest, preacher, scholastic author, and religious mystic, who has been declared a saint and Doctor of the Church by the Catholic Church. He is called the "Apostle of Andalusia", for his extensive ministry in that region
Jan 20 Sebastian Franck a 16th-century German freethinker, humanist, and radical reformer.
Jan 29 Katharina von Bora the wife of Martin Luther, German leader of the Protestant Reformation. Beyond what is found in the writings of Luther and some of his contemporaries, little is known about her. Despite this, Katharina is often considered one of the most important participants of the Reformation because of her role in helping to define Protestant family life and setting the tone for clergy marriages
Feb 10 Thomas Platter a Swiss humanist scholar and writer.
Mar 31 Pope Pius IV Pope from 25 December 1559 to his death in 1565. He is known for presiding over the final session of the Council of Trent
Jun 24 Johannes Brenz a German theologian and the Protestant Reformer of the Duchy of Württemberg.
Jul 17 Maria Salviati an Italian noblewoman, the daughter of Lucrezia di Lorenzo de' Medici and Jacopo Salviati. She married Giovanni dalle Bande Nere and was the mother of Cosimo I de Medici. Her husband died 30 November 1526, leaving her a widow at the age of 27. Salviati never remarried; after her husband's death she adopted the somber garb of a novice, which is how she is remembered today as numerous late portraits show her attired in black and white
Sep 3 Diane de Poitiers a French noblewoman and a prominent courtier at the courts of kings Francis I and his son, Henry II of France. She became notorious as the latter's favourite. It was in this capacity that she wielded much influence and power at the French Court, which continued until Henry was mortally wounded in a tournament accident, during which his lance wore her favour rather than his wife's
Oct 13 Claude of France queen consort of France and duchess regnant of Brittany. She was the eldest daughter of Louis XII of France and Anne of Brittany, as well as the first spouse of Francis I of France
Dec 8 Sebald Heyden a German musicologist, cantor, theologian, hymn-writer and religious poet. He is perhaps best known for his De arte canendi which is considered to have had a major impact on scholarship and the teaching of singing to young boys. It has been speculated that Heyden was the world's first true musicologist
Dec 23 Stephen Zápolya Palatine of the Kingdom of Hungary between 1492 and 1499.