Born in 1500

Jan 16 Antonio Musa Brassavola an Italian physician and one of the most famous of his time. He studied under Niccolò Leoniceno and Manardi. He was the friend and physician of Ercolo II, the prince of Este. He was also the consulting physician of Kings Francis I, Charles V, Henry VIII and Popes Paul III, Leo X, Clement VIII and Julius III. He performed the first successful tracheotomy, and published an account of it in 1546. He was the chair of philosophy in Ferrara and also studied botany and medicine. A genus of orchid, called Brassavola, is named after him
Feb 22 Rodolfo Pio da Carpi an Italian Cardinal, humanist and patron of the arts. He formed a great library and was at the center of humanist studies in 16th-century Rome, though serving on the Roman Inquisition. He was a trusted advisor to Pope Pius III and helped to establish the Inquisition at Milan
Feb 24 Charles V Holy Roman Emperor ruler of the Holy Roman Empire from 1519 and, as Charles I, of the Spanish Empire from 1516 until his voluntary abdication in favor of his younger brother Ferdinand I as Holy Roman Emperor and his son Philip II as King of Spain in 1556.
Feb 27 João de Castro a Portuguese nobleman and fourth viceroy of Portuguese India. He was called Castro Forte by poet Luís de Camões. Castro was the son of Álvaro de Castro, civil governor of Lisbon. His wife was Leonor de Coutinho
Mar 3 Reginald Pole an English cardinal of the Roman Catholic Church and the last Roman Catholic Archbishop of Canterbury, holding the office during the Counter Reformation.
Apr 12 Joachim Camerarius a German classical scholar.
Apr 23 Alexander Ales a Scottish theologian of the school of Augsburg.
May 17 Federico II Gonzaga Duke of Mantua the ruler of the Italian city of Mantua from 1519 until his death. He was also Marquis of Montferrat from 1536
Jul 5 Paris Bordone an Italian painter of the Venetian Renaissance who, despite training with Titian, maintained a strand of mannerist complexity and provincial vigor.
Jul 30 Katie Cecil an American television actress and formerly guitarist/vocalist for the teen power pop/rock band KSM.
Sep 5 Maria of Jever the last ruler of the Lordship of Jever from the Wiemken family.
Nov 3 Benvenuto Cellini an Italian goldsmith, sculptor, draftsman, soldier and musician, who also wrote a famous autobiography. He was one of the most important artists of Mannerism