Born in 1516

Jan 1 Margaret Leijonhufvud Queen of Sweden from 1536 to 1551 as the wife of King Gustav She belonged to the early Leijonhufvud clan of Swedish nobility.
Jan 16 Bayinnaung king of Toungoo Dynasty of Burma from 1550 to 1581. During his 31-year reign, which has been called the "greatest explosion of human energy ever seen in Burma", Bayinnaung assembled the largest empire in the history of Southeast Asia, which included much of modern-day Burma, Chinese Shan states, Lan Na, Lan Xang, Manipur and Siam
Feb 18 Mary I of England Queen of England and Ireland from July 1553 until her death. Her executions of Protestants caused her opponents to give her the sobriquet "Bloody Mary"
Mar 16 Serapion of Novgorod Archbishop of Novgorod the Great and Pskov from 1506 to 1509. He is a saint of the Russian Orthodox Church; his feast day is March 16 by the Julian calendar
Mar 26 Conrad Gessner a Swiss naturalist and bibliographer. He was well known as a botanist, physician and classical linguist. His five-volume Historiae animalium is considered the beginning of modern zoology, and the flowering plant genus Gesneria and its family Gesneriaceae are named after him. A genus of moths is also named Gesneria after him. He is denoted by the author abbreviation Gesner when citing a botanical name
Apr 16 Tabinshwehti king of Toungoo Dynasty of Burma from 1530 to 1550, and the founder of Toungoo Empire. His military campaigns created the largest kingdom in Burma since the fall of Pagan Empire in 1287. His administratively fragile kingdom proved to be the impetus for the eventual reunification of the entire country by his successor and brother-in-law Bayinnaung
Apr 23 Georg Fabricius a Protestant German poet, historian and archaeologist.
Jul 27 Emilie of Saxony the third wife of Margrave George the Pious of Brandenburg-Ansbach. Since his two earlier wives died before his accession, she was the only one to enjoy the title Margravine
Jul 28 William Duke of Jülich-Cleves-Berg a Duke of Jülich-Cleves-Berg. William was born in and died in Düsseldorf. He was the only son of John III, Duke of Jülich-Cleves-Berg, and Maria, Duchess of Jülich-Berg. William took over rule of his father's estates upon his death in 1539. Despite his mother having lived until 1543, William also became the Duke of Berg and Jülich and the Count of Ravenstein
Sep 2 Francis I Duke of Nevers a commander in the French Royal Army and the first Duke of Nevers. He participated in the suppression of the Amboise conspiracy
Sep 21 Matthew Stewart 4th Earl of Lennox the 4th Earl of Lennox, and leader of the Catholic nobility in Scotland. He was the son of John Stewart, 3rd Earl of Lennox. His grandson was James VI of Scotland
Oct 23 Charlotte of Valois the second child and second daughter of King Francis I and his wife Claude.
Nov 5 Martin Helwig a German cartographer of and from Silesia and pedagogue. He was born in Neisse and died in Breslau, Holy Roman Empire