Born in 1520

Feb 22 Moses Isserles also well known for his Darkhei Moshe commentary on the Tur. Isserles is also referred to as the Rema, , the Hebrew acronym for Rabbi Moses Isserles
Mar 3 Matthias Flacius a Lutheran reformer from Istria, present day Croatia.
Aug 1 Sigismund II Augustus King of Poland and Grand Duke of Lithuania, the only son of Sigismund I the Old, whom Sigismund II succeeded in 1548. Married three times, the last of the Jagiellons remained childless, and through the Union of Lublin introduced an elective monarchy
Aug 10 Madeleine of Valois a French princess who became Queen of Scots as the first spouse of King James V.
Sep 13 William Cecil 1st Baron Burghley an English statesman, the chief advisor of Queen Elizabeth I for most of her reign, twice Secretary of State and Lord High Treasurer from 1572. He was the founder of the Cecil dynasty which has produced many politicians including two Prime Ministers
Oct 5 Alessandro Farnese (cardinal) the grandson of Pope Paul III , and the son of Pier Luigi Farnese, Duke of Parma, who was murdered in 1547. He should not be confused with his nephew Alessandro Farnese, Governor of the Spanish Netherlands, grandson of Emperor Charles V and great-grandson of Pope Paul III
Nov 10 Dorothea of Denmark Electress Palatine a Danish, Norwegian and Swedish princess and an electress of the Palatinate as the wife of Elector Frederick II of the Palatinate. She was a claimant to the Danish, Norwegian and Swedish thrones
Dec 6 Barbara Radziwiłł Queen of Poland and Grand Duchess of Lithuania as consort to Sigismund II Augustus.
Dec 13 Pope Sixtus V Pope from 24 April 1585 to his death in 1590. To date, he is the last pontiff to take the pontifical name of "Sixtus" upon his election