Died in 1521

Mar 15 John II Duke of Cleves a son of John I, Duke of Cleves and Elizabeth of Nevers. He ruled Cleves from 1481 to his death in 1521. He was called "The Babymaker" since he fathered sixty-three illegitimate children before his marriage with Mathilde of Hesse in 1490. She was the daughter of Henry III, Landgrave of Upper Hesse and his wife Anna of Katzenelnbogen
Apr 8 William II of Pernstein a Moravian-Bohemian nobleman. He held the office of High Treasurer of Moravia from 1474 to 1487. He was High Marshall of Bohemia from 1483 to 1490 and Lord Chamberlain of Bohemia from 1490 to 1514
Apr 20 Zhengde Emperor the Ming dynasty Emperor of China between 1505–1521. Born Zhu Houzhao, he was the Hongzhi Emperor's eldest son. His era name means "Right virtue" or "Rectification of virtue"
Apr 27 Ferdinand Magellan a Portuguese explorer who organised the Spanish expedition to the East Indies that resulted in the first circumnavigation of the Earth, completed by Juan Sebastián Elcano.
Apr 28 Suzanne Duchess of Bourbon suo jure Duchess of Bourbon and Auvergne from 1503 to her death. Her husband was Charles de Bourbon
May 10 Sebastian Brant a German humanist and satirist. He is best known for his satire Das Narrenschiff
May 17 Edward Stafford 3rd Duke of Buckingham an English nobleman. He was the son of Henry Stafford, 2nd Duke of Buckingham, and Katherine Woodville, whose sister, Queen Elizabeth Woodville, was the wife of King Edward He was convicted of treason, and executed on 17 May 1521
May 23 Thomas Stanley 2nd Earl of Derby an English peer.
Jun 15 Tamás Bakócz a Hungarian archbishop, cardinal and statesman.
Jun 21 Leonardo Loredan the doge of the Republic of Venice from 1501 until his death, in the course of the War of the League of Cambrai.
Aug 27 Josquin des Prez a Franco-Flemish composer of the Renaissance. His original name is sometimes given as Josquin Lebloitte and his later name is given under a wide variety of spellings in French, Italian, and Latin, including Josquinus Pratensis and Jodocus a Prato. His motet Illibata Dei virgo nutrix includes an acrostic of his name, where he spelled it "Josquin des Prez". He was the most famous European composer between Guillaume Dufay and Palestrina, and is usually considered to be the central figure of the Franco-Flemish School. Josquin is widely considered by music scholars to be the first master of the high Renaissance style of polyphonic vocal music that was emerging during his lifetime
Dec 1 Pope Leo X Pope from 9 March 1513 to his death in 1521. The second son of Lorenzo the Magnificent, ruler of the Florentine Republic, he was elevated to the cardinalate in 1489
Dec 8 Christina of Saxony a Saxon princess who became Queen consort of Denmark, Norway, and Sweden. She was born a granddaughter of Frederick the Gentle of Saxony, and daughter of Ernest, Elector of Saxony and Elisabeth of Bavaria. She was the grandmother of Christina of Denmark through her son Christian II
Dec 13 Manuel I of Portugal the son of Infante Ferdinand, Duke of Viseu, , by his wife, Infanta Beatrice of Portugal. His name is associated with a period of Portuguese civilization distinguished by significant achievements both in political affairs and the arts. In spite of its small size and population in comparison to the great land powers of Europe, it was able to acquire an overseas empire of vast proportions and with a global dimension, for the first time in history, during Manuel's reign