Died in 1526

Jan 19 Isabella of Austria Queen of Denmark, Sweden and Norway as the wife of King Christian She was the daughter of King Philip I and Queen Joanna of Castile and the sister of Emperor Charles She was born at Brussels. She served as regent of Denmark in 1520
Feb 23 Diego Columbus a Portuguese navigator and explorer. He served as the 2nd Admiral of the Indies, 2nd Viceroy of the Indies and 3rd Governor of the Indies. He was the eldest son of Christopher Columbus and wife Filipa Moniz Perestrelo
Mar 10 Janusz III of Masovia a Polish duke of Masovia, and the last male of the Masovian Piast dynasty.
Mar 15 Charles Somerset 1st Earl of Worcester the legitimised bastard son of Henry Beaufort, 3rd Duke of Somerset by his mistress Joan Hill.
Mar 30 Konrad Mutian a German humanist. He was born in Homburg of well-to-do parents named Muth, and was subsequently known as Konrad Mutianus Rufus from his red hair
May 19 Emperor Go-Kashiwabara the 104th emperor of Japan, according to the traditional order of succession. He reigned from November 16, 1500 to May 19, 1526. His personal name was Katsuhito. His reign marked the nadir of Imperial authority during the Ashikaga shogunate
Jun 4 Francisco Fernández de la Cueva 2nd Duke of Alburquerque a Spanish nobleman.
Jul 20 García Jofre de Loaísa a 16th-century Spanish explorer ordered by King Charles I of Spain to command an expedition to Asia, known as the Loaísa expedition, which in 1525 was sent by the western route to colonize the Spice Islands in the East Indies, thus crossing the Atlantic and Pacific oceans. More than 450 men were aboard, including different kinds of trades and administrative staff, intended to establish a permanent Spanish settlements in the Spanish East Indies
Aug 4 Juan Sebastián Elcano a Spanish Basque explorer who completed the first circumnavigation. After Magellan's death in the Philippines, Elcano took command of the nau Victoria from the Moluccas to Sanlúcar de Barrameda in Spain
Aug 29 Louis II of Hungary King of Hungary, Croatia and King of Bohemia from 1516 to 1526. He was killed during the Battle of Mohács fighting the Ottomans
Aug 29 Pál Tomori a Catholic monk and archbishop of Kalocsa, Hungary. He defeated an Ottoman army near Sremska Mitrovica in 1523
Sep 4 John Stewart 3rd Earl of Lennox a prominent Scottish magnate. He was the son of Matthew Stewart, 2nd Earl of Lennox, and Elizabeth Hamilton, daughter of James Hamilton, 1st Lord Hamilton and Mary Stewart, Princess of Scotland, daughter of King James II of Scotland
Nov 5 Scipione del Ferro an Italian mathematician who first discovered a method to solve the depressed cubic equation.
Nov 30 Giovanni dalle Bande Nere an Italian condottiero.