Died in 1539

Feb 6 John III Duke of Cleves a son of John II, Duke of Cleves and Mathilde of Hesse, daughter of Henry III, Landgrave of Upper Hesse.
Feb 13 Isabella d'Este Marchesa of Mantua and one of the leading women of the Italian Renaissance as a major cultural and political figure. She was a patron of the arts as well as a leader of fashion, whose innovative style of dressing was copied by women throughout Italy and at the French court. The poet Ariosto labeled her as the "liberal and magnanimous Isabella", while author Matteo Bandello described her as having been "supreme among women". Diplomat Niccolò da Correggio went even further by hailing her as "The First Lady of the world"
Mar 5 Nuno da Cunha a governor of Portuguese possessions in India from 1528 to 1538. He was the son of Antónia Pais and Tristão da Cunha, the famous Portuguese navigator, admiral and ambassador to Pope Leo Nuno da Cunha proved his mettle in battles at Oja and Brava, and at the capture of Panane, under the viceroy Francisco de Almeida. Named by João III ninth governor of Portuguese possessions in India, he served from April 1528 to 1538
Mar 12 Thomas Boleyn 1st Earl of Wiltshire an English diplomat and politician in the Tudor era. He was born at the family home, Hever Castle, Kent, which had been purchased by his grandfather Geoffrey Boleyn, who was a wealthy mercer. He was buried at Peter's parish church in the village of Hever. His parents were Sir William Boleyn and Lady Margaret Butler. He was the father of Anne Boleyn, the second wife of Henry VIII of England. As such, he was the maternal grandfather of Queen Elizabeth I
Apr 17 George Duke of Saxony duke of Saxony from 1500 to 1539.
May 1 Isabella of Portugal an Infanta of Portugal, by birth, and a Holy Roman Empress, Queen of Germany, Italy, Spain, Naples and Sicily, Duchess of Burgundy etc. as the spouse of Charles V, Holy Roman Emperor. She was the daughter of Manuel I of Portugal and Maria of Aragon. She served as regent of Spain during the absence of her spouse for long periods
May 7 Ottaviano Petrucci an Italian printer. His Harmonice Musices Odhecaton, a collection of chansons printed in 1501, is commonly misidentified as the first book of sheet music printed from movable type. Actually that distinction belongs to the Roman printer Ulrich Han's Missale Romanum of 1476. Nevertheless, Petrucci's later work was extraordinary for the complexity of his white mensural notation and the smallness of his font, and he did in fact print the first book of polyphony using movable type. He also published numerous works by the most highly regarded composers of the Renaissance, including Josquin des Prez and Antoine Brumel
Jul 5 Anthony Maria Zaccaria an early leader of the Counter Reformation. His feast day is celebrated on 5 July
Jul 9 Adrian Fortescue (martyr) a courtier at the court of King Henry VIII of England who was executed in 1539 and later beatified as a Roman Catholic martyr.
Jul 19 Lorenzo Campeggio an Italian cardinal and politician. He was the last cardinal protector of England
Sep 8 John Stokesley an English church leader who was Catholic Bishop of London during the reign of Henry VIII.
Sep 22 Guru Nanak the founder of Sikhism and the first of the Sikh Gurus. His birth is celebrated world-wide on Kartik Puranmashi, the full-moon day which falls on different dates each year in the month of Katak, October–November
Dec 20 Johannes Lupi a Franco-Flemish composer of the Renaissance. A representative of the generation after Josquin, he was a minor but skilled composer of polyphony who was mainly active in Cambrai