Died in 1541

Jan 6 Bernard van Orley a Flemish Northern Renaissance painter and draughtsman, and also a leading designer of Brussels tapestry and stained glass. He belongs to the group of Italianizing Flemish painters called the Romanists, who were influenced by Italian Renaissance painting
Apr 29 Johann Gramann a German pastor, theologian, teacher, humanist, reformer, and Lutheran leader.
May 21 Johann Faber a Catholic theologian known for his writings opposing the Protestant Reformation and the growing Anabaptist movement.
May 27 Margaret Pole Countess of Salisbury an English peeress. She was the daughter of George, Duke of Clarence, who was the brother of King Edward IV and King Richard III. She was one of two women in sixteenth-century England to be a peeress in her own right with no titled husband. One of the few surviving members of the Plantagenet dynasty after the Wars of the Roses, she was executed in 1541 at the command of King Henry VIII, who was the son of her cousin Elizabeth of York. Pope Leo XIII beatified her as a martyr for the Roman Catholic Church on 29 December 1886
Jun 26 Francisco Pizarro a Spanish conquistador who conquered the Incan Empire.
Jul 4 Pedro de Alvarado a Spanish conquistador and governor of Guatemala. He participated in the conquest of Cuba, in Juan de Grijalva's exploration of the coasts of Yucatan and the Gulf of Mexico, and in the conquest of Mexico led by Hernán Cortés. He is considered the conquistador of most of Central America. Although renowned for his skill as a soldier, Alvarado is known also for the cruelty of his treatment of native populations, and mass murders committed in the subjugation of the native peoples of Mexico. Historiography portrays that indigenous people, both Nahuatl-speakers and speakers of other languages, called him Tonatiuh, meaning "sun" in the Nahuatl language. Yet he was also called "Red Sun" in Nahuatl, which allows a variety of interpretations. Whether this epithet refers to Don Alvarado's red hair, some esoteric quality attributed to him, or both, is disputed
Aug 1 Simon Grynaeus a German scholar and theologian of the Protestant Reformation.
Aug 10 Hōjō Ujitsuna the son of Hōjō Sōun, founder of the Go-Hōjō clan. He continued his father's quest to gain control of the Kantō
Aug 18 Henry IV Duke of Saxony a Duke of Saxony from the House of Wettin.
Sep 24 Paracelsus a Swiss German Renaissance physician, botanist, alchemist, astrologer, and general occultist. He founded the discipline of Toxicology. He is also known as a revolutionary for insisting upon using observations of nature, rather than looking to ancient texts, in open and radical defiance of medical practice of his day. He is also credited for giving zinc its name, calling it zincum. Modern psychology often also credits him for being the first to note that some diseases are rooted in psychological illness
Oct 18 Margaret Tudor the elder of the two surviving daughters of Henry VII of England and Elizabeth of York, and the elder sister of Henry VIII. In 1503, she married James IV, King of Scots. James died in 1513, and their son became King James She married secondly Archibald Douglas, 6th Earl of Angus. Through her first and second marriages, respectively, Margaret was the grandmother of both Mary, Queen of Scots, and Mary's second husband, Lord Darnley. Margaret's marriage to James IV foreshadowed the Union of the Crowns - their great-grandson, King James VI of Scotland, the child of Mary and Darnley, also became the king of England and Ireland on the death of Margaret's fraternal niece, Elizabeth I of England in 1603
Dec 10 Thomas Culpeper a courtier and close friend of Henry VIII, and related to two of his queens, Anne Boleyn and Catherine Howard. He is known to have had many private meetings with Catherine after her marriage, though these may have involved political intrigue only, as the one letter she is known to have written him does not seem to suggest intimacy. But under torture, he confessed to adultery, and both were beheaded for treason
Dec 15 Johanna Maria van der Gheynst in 1521-1522, for a short time, the mistress of the Emperor Charles V and bore him a daughter, Margaret of Parma, who was Governor of the Netherlands from 1559 to 1567 and from 1580 to 1583.
Dec 24 Andreas Karlstadt a German Christian theologian during the Protestant Reformation. He was born in Karlstadt, Franconia