Died in 1542

Feb 1 Girolamo Aleandro an Italian cardinal, and the first cardinal appointed in pectore.
Feb 13 Catherine Howard Queen of England from 1540 until 1541, as the fifth wife of Henry VIII who referred to her as his "rose without a thorn". Catherine married Henry on 28 July 1540, at Oatlands Palace, in Surrey, almost immediately after the annulment of his marriage to Anne of Cleves was arranged. Catherine was beheaded after less than two years of marriage to Henry on the grounds of treason for committing adultery while married to the King. She was the third of Henry's wives to have been a member of the English gentry instead of European nobility
Feb 13 Jane Boleyn Viscountess Rochford a sister-in-law of King Henry VIII of England. She was the wife of George Boleyn, 2nd Viscount Rochford, brother of Henry's second wife, Anne Boleyn. Jane had a small role in the judgments and subsequent executions of her husband and of two of Henry's wives, and was a lady-in-waiting to a fourth. Lady Jane also served as lady-in-waiting to her cousin-in-law, Henry's fifth wife, Catherine Howard, with whom she was executed
Mar 1 Bia de' Medici the illegitimate daughter of Cosimo I de' Medici, Grand Duke of Tuscany, born before his first marriage.
Mar 17 Angelo Beolco an Italian actor and playwright.
May 21 Hernando de Soto a Spanish explorer and conquistador who led the first European expedition deep into the territory of the modern-day United States , and the first documented European to have crossed the Mississippi River.
Jun 19 Leo Jud born in 1482 in Guémar, Alsace, southwest of Strasbourg. Like his later colleague Heinrich Bullinger, Jud was the son of a priest. His father, Johannes Jud, was from Guémar and his mother, Elsa Hochsang, was from Solothurn. He studied at the Latin school in Sélestat with Martin Bucer and in 1499 he matriculated at the University of Basel, where he met Huldrych Zwingli. He began his studies in medicine but switched to theology under the influence of Thomas Wyttenbach. Leo Jud is one of the lesser-known leaders of the Swiss Reformed Church, but his influence was extensive
Jul 15 Lisa del Giocondo a member of the Gherardini family of Florence and Tuscany in Italy. Her name was given to Mona Lisa, her portrait commissioned by her husband and painted by Leonardo da Vinci during the Italian Renaissance
Aug 24 Gasparo Contarini an Italian diplomat, cardinal and Bishop of Belluno. He was one of the first proponents of the dialogue with Protestants, after the Reformation
Aug 29 Cristóvão da Gama a Portuguese military commander who led a Portuguese army of 400 musketeers on a crusade in Ethiopia and Somalia against the far larger Somali Muslim army of Imam Ahmad ibn Ibrahim al-Ghazi aided by the Ottoman Empire. He was victorious against larger forces in four battles, but was seriously wounded in his last battle, after which he was captured and eventually executed. Sir Richard Burton, in his First Footsteps in East Africa, referred to him as "the most chivalrous soldier of a chivalrous age."
Sep 16 Diego de Almagro II the assassin of Spanish conquistador Francisco Pizarro. El Mozo, named Diego de Almagro after his father, was the son of the famous Diego de Almagro and a native Panama Indian
Oct 11 Thomas Wyatt (poet) a 16th-century English ambassador and lyrical poet. He is credited with introducing the sonnet into English literature. He was born at Allington Castle, near Maidstone in Kent, though his family was originally from Yorkshire. His mother was Anne Skinner and his father, Henry Wyatt, had been one of Henry VII's Privy Councillors, and remained a trusted adviser when Henry VIII came to the throne in 1509. In his turn, Thomas Wyatt followed his father to court after his education at St John's College, Cambridge. None of Wyatt's poems were published during his lifetime—the first book to feature his verse, Tottel's Miscellany of 1557, was printed a full fifteen years after his death
Dec 14 James V of Scotland King of Scots from 9 September 1513 until his death, which followed the Scottish defeat at the Battle of Solway Moss. His only surviving legitimate child, Mary, succeeded him to the throne when she was just six days old
Dec 18 Solomonia Saburova the first wife of Grand Prince Vasili III of Muscovy. She was canonized by the Russian Orthodox Church as Saint Sofia of Suzdal
Dec 22 Hieronymus Łaski a Polish diplomat born of an illustrious Polish family. Laski was the nephew of Archbishop John Laski and served as palatine of Inowrocław and of Sieradia, Sieradz
Dec 28 Albert Pighius a Dutch Roman Catholic theologian, mathematician, and astronomer.