Eleonora di Garzia di Toledo
the daughter of García Álvarez de Toledo, 4th Marquis of Villafranca, Duke of Fernandina, and the wife of Don Pietro de' Medici, a son of Cosimo I de' Medici, Grand Duke of Tuscany.
Leonora was born in Florence, where she was brought up by Cosimo and Eleanor of Toledo, her aunt and namesake. Betrothed to their son Pietro at the age of 15, she blossomed under the wing of Pietro's older sister, the artistic patron Isabella, into a vivacious and witty beauty. Her marriage, like Isabella's, was not a success, and she followed her mentor's example of taking lovers. For this reason, Pietro had her brought in 1576 to the country retreat of Cafaggiolo, where he strangled her to death with a dog leash. Cosimo's successor, Francesco I, tacitly approved the murder, and Pietro was never brought to justice for it
Isabella de' Medici
the daughter of Cosimo I de' Medici, first Grand Duke of Tuscany, and Eleonora di Toledo.
She was raised and educated in a humanist manner with her siblings, including Francesco de' Medici who succeeded their father as the Grand Duke of Tuscany. To secure a relationship with the powerful Roman Orsinis, Isabella's father arranged her marriage to Paolo Giordano I Orsini when she was 16. She remained in her father's household after her marriage, giving her an unusual degree of independence for a woman of her period. Following the death of her father, Isabella was probably murdered, with the complicity of her husband and brother, and in retribution for her relationship with Paolo Giordano's cousin Troilo Orsini